Vol. 7, Issue 2, Part A (2025)

The restrictions of current radiation therapy, chemotherapy, and surgical methods such as toxicology, drug resistance, and considerable cost have led to a large need for less dangerous and more effective remedies. Malignancy is a major worldwide health epidemic that claims millions of lives each year. Given their varied pharmacological characteristics and low side effects, phytochemicals bioactive substances derived from plants have shown great promise as cancer prevention and treatment agents. The anticancer potential of several important phytochemical classes, such as volatile alkaline substances, terpenoids, polyphenols, and saponins, is examined in this systematic review. By altering important biological processes implicated in dividing cells, dying off, angioplasty metastasis, and oxidative stress, these compounds have been shown in numerous studies to have anticancer effects.
In a variety of in vitro and in vivo models, compounds like lycopene, curcumin, resveratrol, quercetin, and epigallocatechin gallate (EGCG) have demonstrated strong anticancer activity. Furthermore, the distribution and therapeutic effectiveness of these phytochemicals have been enhanced by developments in drug delivery systems based on nanotechnology. The review also emphasizes how phytochemicals and traditional chemotherapeutic agents can work in concert to improve the results of cancer treatment. To confirm preclinical results and guarantee the compounds' safety, stability, and ideal dosage, more clinical research is necessary. All things considered, phytochemicals are a critical resource for the creation of new, less harmful anticancer drugs that can enhance current treatment modalities and enhance patient care.