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International Journal of Pharmacognosy and Pharmaceutical Sciences

Vol. 6, Issue 1, Part A (2024)

Cannabinoids and its disease targeting mechanisms for Parkinson's Disease and Cancer

Author(s):

Rajnandan Borah, Manoleena Sarkar, Rajat Das, Chandrika Sharma, Pallab Ghosh and Jyochhana Priya Mohanty

Abstract:

Background: Endocannabinoids, Phyto-cannabinoids and synthetic cannabinoids are the three categories of cannabinoids. The way that various cannabinoids attach to endocannabinoid receptors determines the physiological effects that they have.
Cannabinoids treatment: Enzymes that catalyse the synthesis and degradation of endocannabinoids, together with cannabinoid receptors, comprise the endocannabinoid system. The placement of the receptor within neurons is consistent with the well-known motor activities of cannabis. The main organ where the cannabis CB1 receptor is connected is the nervous system. CB2 and CB1 are currently the two recognized cannabinoid receptors. Bradykinesia, or slowness of movement, is another symptom that people with Parkinson's disease (PD) may have in addition to fatigue, forgetfulness, tense muscles, and strange vocal tones. It stems from the degeneration of the basal ganglia, which can be brought on by gene mutations, inflammatory stress, misfolded protein aggregation, or the production of free radicals. It mostly impacts the body's neuromuscular coordination. A group of diseases collectively referred to as cancers are distinguished by abnormal cell growth that has the potential to invade or spread to other body parts. 
Conclusion: More than 100 distinct forms of cancer that affect the body and can affect humans. By building a common connection in the main secondary messenger that may interact with the target protein, we have attempted to establish a linkage between Parkinson's disease and cancer. Cannabinoids are thought to be the basis of cure for both the disorders.
 

Pages: 28-34  |  185 Views  59 Downloads


International Journal of Pharmacognosy and Pharmaceutical Sciences
How to cite this article:
Rajnandan Borah, Manoleena Sarkar, Rajat Das, Chandrika Sharma, Pallab Ghosh and Jyochhana Priya Mohanty. Cannabinoids and its disease targeting mechanisms for Parkinson's Disease and Cancer. Int. J. Pharmacognosy Pharm. Sci. 2024;6(1):28-34. DOI: 10.33545/27067009.2024.v6.i1a.135
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