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International Journal of Pharmacognosy and Pharmaceutical Sciences

Vol. 6, Issue 1, Part A (2024)

A comparative study to assess effect of discontinuation of proton pump inhibitors (PPIs) after 48 hours on admission in critical care unit on incidents of nosocomial pneumonia

Author(s):

Besty Varghese

Abstract:

Aim and Background: The aim of this study was to determine whether the use of gastric acid-suppressive agents increases the risk of NP in Critical care.
Methods: The methodology adopted for experimenting with the effectiveness of PPI use in two study groups and evaluated the result with the help of APACHE II and CPIS calculator. The researcher divided patients into two groups after initiation of enteral feeding on a random basis, one group of patients with PPI and another group without PPI. Both of the groups were evaluated for the risk of suspected HAI with the guidance of APACHE-II, GCS, and CPIS.
Results: Overall, out of 60 patients, further divided into two groups Pre-operative ICU mortality for patients from PPI group (11.13) was lower than patients from No PPI group (12.77). Mean Post-operative ICU mortality for patients from the PPI group (5.43) was lower than patients from No PPI group (6.77). Mean APACHE II score for patients from PPI group (7.83) was lower than patients from the No PPI group (9.13). CPIS I score for patients from PPI group (1.83) was lower than patients from No PPI group (2.13). From findings, an unpaired t-test was done to compare. There was no significant difference between the two groups (p>0.05) indicating very few cases of NP.
Conclusion: In short, prior use of a PPI did not correlate increase in the risk of developing NP. Apart from PPI, there are a plethora of treatments, and nursing care received by critical patients with various physical illnesses and symptoms.

Pages: 01-07  |  227 Views  76 Downloads


International Journal of Pharmacognosy and Pharmaceutical Sciences
How to cite this article:
Besty Varghese. A comparative study to assess effect of discontinuation of proton pump inhibitors (PPIs) after 48 hours on admission in critical care unit on incidents of nosocomial pneumonia. Int. J. Pharmacognosy Pharm. Sci. 2024;6(1):01-07. DOI: 10.33545/27067009.2024.v6.i1a.131
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