Vol. 5, Issue 2, Part A (2023)

Background: Interleukin -33 is a cytokine that has role pro- and anti-inflammatory effects engaged in the development of many inflammatory diseases. The current study tested the relationship between bacterial prostate inflammation and IL-33 serum levels in the development of infertility in male. 
Aim: The current study aimed to estimate the part that bacterial prostate inflammation and IL-33 function in the development of infertility in male in Najaf governorate.
Method: The patients (120) were examined at the infertility unit in AL-Sadder Medical City, Al-Najaf governorate during the period from January to May of 2022. The patients were divided into categories: 60 prostatitis–related infertile men, 30 prostatitis-fertile men, and 30 infertile men compared with 30 healthy fertile men. Taken blood to measure IL-33 concentration by ELISA and semen samples were to identify the bacterial etiology as well as liquefaction of semen, appearance, volume, and basic sperm properties in the remaining semen (motility, viability, density, and morphology).
Result: The current study saw that patients with Prostatitis had greatly higher serum concentrations of IL-33 than infertile patients, the results were statistically significant (p<0.05). In addition, IL-33 concentration increased with the severity of the disease. 
Conclusion: The Present study establishes a connection between the infection with prostatitis and infertility, which is reflected in the immune response of the body at a higher level of IL-33.