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International Journal of Pharmacognosy and Pharmaceutical Sciences

Vol. 5, Issue 2, Part A (2023)

Green synthesis of pyrazole derivatives by using nano-catalyst


Suresh HM and Suresha Kumara TH


Background: Pyrazole is a simple aromatic ring an organic compound of the heterocyclic scaffolds viz are character five-membered structure whichever consist of two adjacent nitrogen and three carbon atoms respectively. In present days very importance to reduce environment pollution from the synthetic reactions by the utility homogeneous catalyst and organic solvents in synthetic procedures our interest is to develop green synthetic protocol for synthesis of substituted pyrazole derivatives only because their extensive medicinal as well as pharmaceutical applications has increases many a wide range of new investigations in heterocyclic chemistry. Substituted Pyrazoles were also successfully implemented so many routes as antitumor, anti-inflammatory antipsychotic, antimicrobial and antifungal activities. Due to expansive medicinal properties of substituted pyrazole moieties till today quite interesting. 
Methods: Research ideology and on-going content related to microwave irradiated green synthesis of substituted pyrazole structures are clearly report. Fragments are used illustrate central themes about synthetic organic chemistry material bearing substituted pyrazole derivatives.
Results: Brand new substituted α, β-Phenyl Pyrazoles and α, β-hydrazide Pyrazoles was synthesized by microwave heating directly from α, β-diketones and phenyl hydrazine, hydrazine hydrate via a cobalt oxide catalysed coupling reaction in green solvent medium, 
Conclusion: Substituted pyrazoles were prepared via microwave irradiated using Nano catalyst solvent mediated at RMT. A green synthetic protocol which is zone-friendly and advisable method for the preparation of pyrazoles in the presence of heterogeneous catalyst in solvent medium. This method produced excellent yields in terms of minutes therefore; this simple method would be practical for green synthesis of potentially valuable derivatives.

Pages: 12-19  |  257 Views  78 Downloads

International Journal of Pharmacognosy and Pharmaceutical Sciences
How to cite this article:
Suresh HM and Suresha Kumara TH. Green synthesis of pyrazole derivatives by using nano-catalyst. Int. J. Pharmacognosy Pharm. Sci. 2023;5(2):12-19. DOI: 10.33545/27067009.2023.v5.i2a.127
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