Vol. 5, Issue 1, Part A (2023)

Amyloidosis is a rare and serious disease. Amyloidosis occurs when normal proteins in the body become misshapen and clump together. Amyloidosis is causing organ dysfunction and death. Amyloid protein deposits can be found in specific organs, such as the lungs, skin, bladder, or bowel, with systemic amyloidosis being the most common. Although it is not a single type of cancer, it may be associated with some blood cancers such as multiple myeloma, which makes it difficult to study. However, over the past few decades doctors and researchers have begun to understand more about amyloidosis. Research is ongoing to learn more about this disease, which can be fatal. Many different proteins can cause amyloid deposits such as AL amyloidosis, AA amyloidosis, dialysis-related amyloidosis (DRA), familial, or hereditary amyloidosis, age-related (senile). While systemic amyloidosis, and organ-specific amyloidosis, certain types of amyloid deposits have been associated with Alzheimer's disease, the brain is rarely affected by amyloidosis that occurs throughout your body. If amyloidosis can prevent the accumulation of amyloid in the patient's brain, then we can bring amyloidosis under control to a great extent.