Sarvan Kumar Guguloth, Hari Prasad Murthy CH, Konijeti Srinivas Rao and Laxmi Devi BN
The present research work investigates the effect of methanolic leaf extracts of Terminalia chebula in vivo by using wester albino rats. The acute oral toxicity of methanolic leaf extracts of the Terminalia chebula was studied by Lorke method. Lethal dose (LD 50) of the plant extract was entrenched and experimental rats were divided into 4 groups and then rats were administered with various concentration of leaf methanolic extracts (50 mg/kg, 100 mg/kg and 200 mg/kg) respectively. To analyze the hematological parameters, blood was withdrawn from the retro orbital puncture. The LD50 was calculated at 547.72 mg/kg. There was no significant change in hematological parameters (p>0.05) were observed when group I compared with group II which was administered with the dose of 50 mg/kg methanolic leaf extracts of the Terminalia chebula. While group III of which received100 mg/kg of plant methanolic leaf extract of Terminalia chebula showed significance (p<0.05) reduction in the packed cell volume (PCV), hemoglobin (Hb) and also reduction in the platelet count. At 100 mg/kg, the plant methanolic leaf extract showed significant anti platelet activity (p<0.05). The plant extracts at the dose of 200 mg/kg, showed significant increase in the concentration of hemoglobin, and indicates that can be used in the treatment of anemia. It can be concluded that the methanolic leaf extracts of Terminalia chebula exhibited hematinic, anti-platelet as well as anti-coagulation activity.
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