Vol. 3, Issue 1, Part A (2021)

Solid dispersions in water-soluble carriers have piqued researchers' interest as a way to boost the dissolution rate, and thus the bioavailability, of a variety of hydrophobic drugs. Despite its many benefits, strong dispersion has a number of significant disadvantages. One of the most serious issues is the physical stability of the drug's high-energy amorphous state. Since solid dispersion aids in improving dissolution and solubility, the drug in an amorphous state can crystallise over time. This review focuses on the factors that aid in the improvement of solid dispersion's physical stability. The consequences of a better understanding of physical stability are addressed, with a focus on optimising the carrier-to-drug ratio, carrier selection, and the estimation of the glass transition temperature of the drug. The medication and the carrier, as well as the physical changes in solid dispersions that lead to crystallisation.