Vol. 2, Issue 2, Part A (2020)

The present study is to evaluate the preventive role of Ageratum conyzoides L. on mitochondrial enzymes such as isocitrate dehydrogenase (ICDH), succinate dehydrogenase (SDH), malate dehydrogenase (MDH), and α-ketoglutarate dehydrogenase (α-KGDH) and respiratory chain enzymes such as NADH dehydrogenase and cytochrome c oxidase in isoproterenol (ISO)- induced myocardial infarction (MI) in male albino Wistar rats. Rats were orally pre-treated with Ageratum conyzoides L. (100 and 200 mg/kg) to ISO-induced rats daily for a period of 56 days. After the treatment, rats were subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for 2 days. ISO induction also showed a significant (p<0.05) decrease in the activities of enzymes such as ICDH, SDH, MDH, α-KGDH, NADH dehydrogenase, and cytochrome c oxidase. Pre-treatment with Ageratum conyzoides L. significantly (p< 0.05) altered all the biochemical parameters and regulated the normal mitochondrial function. Transmission electron microscopic (TEM) study also correlated with these biochemical findings. Thus, the present study findings demonstrate that Ageratum conyzoides L. possesses excellent cardioprotective activity by preventing alterations in ISO-induced MI in rats.