S Raisa Fathima, R Manohar Reddy, Dr. S Nelson Kumar, Dr. C Rajaram and Dr. K Ravindra Reddy
The aim of the study is to protective effect of ethanolic leaf extract of cleome gyanandra on gentamicin induced nephrotoxic rats. Nephrotoxicity is also known as toxic kidney disease. This is caused by aristolochic acid that is present in the body and causes injury or damage to the kidney.The model of gentamicin induced nephrotoxicity is considered as one of the most widely used experimental model to study the useful effects of many drugs and kidney function. The acute oral toxicity study was done according to OECD 423 guidelines. Wistar albino rats of either sex were selected randomly. The animals were fasted overnight, doses of 100, 250, 500, 1000, 2000, 3000 and 5000mg/kg body weight, were administered orally. The experimental animals were randomly divided in to 5 groups (n= 6). At the experiments: the pharmacological studies like acute toxicity studies, nephro protective activity like biochemical parameters in serum: i) renal biomarkers i.e., decrease of serum uric acid, urea, bun, creatinine levels, total serum proteins by increasing dose ii) non renal biomarkers i.e., higher dose is more effective in decreasing bilirubin, serum cholesterol, serum glucose level than lower dose. Bio-chemical parameters in urine like urea, uric acid, creatinine decreases as the dose increases. It seems that Cleome Gyanandra are able to improve kidney function against GM-induced nephrotoxicity. In this study it indicates that Cleome Gyanandra have shown a good nephroprotective activity by decreasing serum renal markers, serum non renal parameters and morphological parameters.
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