Due to huge achievements in drug delivery system, excipients are presently included in novel drug delivery system to serve particular roles and in some cases; they directly or indirectly affect the extent and rate of drug release and drug absorption. Excipients are used from artificial resources in the up-to-date era, causing undesirable pharmaceutical and therapeutic impact. Natural excipients are plant or plant-based substances, obtained from many components of the plant. Thus, companies and customers are therefore looking at natural resources as they believe that anything natural will be safer and without side effects and can be used to solve toxicity and chemical compatibility issue of synthetic excipient’s in different drug delivery systems. This article is an effort to review natural excipients in existing dosage forms as well as new drug delivery systems to serve humanity by ensuring safe, effective, quality and price-effective medical superiority worldwide.