Prakash Mishra, Anas Khan, Ashra Khokar, Sarita Karole, Sarika Shrivastava, Anup Chakraborty
Plant extracts contains huge number of chemical compounds, making them a rich source of different types of medicines. Thus, a proper scientific evidence or assessment has become the criteria for acceptance of herbal health claims. As such developing a polyherbal formulation will definitely produce synergistic effect as needed comparable to single extract or standard drugs that are available in market all over the world. Plants are the richest source for antioxidant and are effective in the management of oxidative stress, caused by free radical damage. The objective of this study is to determine phytochemical and the optimum antioxidant properties of polyherbal formulations of the methanolic extract of leaves of Phyllanthus emblica (Amla), Moringa oleifera (Drumstick) and Citrus limon (Lemon) using in vitro method. Phytochemical screening showed the presence of alkaloids, glycosides, carbohydrates, amino acid, tannin, steroids, and flavonoids in the individual extracts. The antioxidant study of the individual extracts and polyherbal formulation were conducted using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging assay method. Synergy is the interaction of two or more extracts to produce a combined effect greater than the totality of their individual effects. The results suggest that P. emblica has higher potential of antioxidant properties. Synergistic effect was exhibited in polyherbal formulation. In conclusion, the results indicated that the formulations obtained in this present study justify the promising antioxidant properties of the polyherbal mixtures. Thus, it is sensible to use the combination of studied herbal formulation for development of any antioxidant supplement or food products in the future.
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